반응 #549352
ord-9e3de2bcf77e4844acc9acdb34837ae2
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도The mixture is refluxed for 16 hours
- 2온도cooled
- 3기타After removing the ethanol in vacuo
- 4기타the product precipitates out of the aqueous residue
- 5여과It is collected by filtration
- 6세척washed with water
- 7기타dried
실험 절차
To a solution of 21.8 g (0.20 mole) of 2-cyanothiophene in 500 ml of ethanol, 13.9 g (0.20 mole) of hydroxylamine HCl is added, followed by the addition of 13.8 g (0.10 mole) of K2CO3 in 50 ml of water. The mixture is refluxed for 16 hours, cooled and diluted with 200 ml of water. After removing the ethanol in vacuo, the product precipitates out of the aqueous residue. It is collected by filtration, washed with water and dried to yield 22.4 g (80%) of product, m.p. 70°-75°.