반응 #54933
ord-51634a379c774f2fb0c7ff187d1ea7c9
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도is heated
- 2온도to reflux for 2.5 hours
- 3기타After this time, the reaction vessel is fitted with a Dean-Stark trap
- 4온도heated
- 5온도at reflux an additional thirty minutes
- 6농축The reaction mixture is concentrated in vacuo
실험 절차
A mixture of ethyl-2-(diethoxyphosphinyl)propionate (15 g., 0.063 moles) in 6 N hydrochloric acid (150 ml.) is heated to reflux for 2.5 hours. After this time, the reaction vessel is fitted with a Dean-Stark trap and heated at reflux an additional thirty minutes. The reaction mixture is concentrated in vacuo to yield 2-phosphonopropionic acid (quantitative).