반응 #54927

반응 방정식

o-toluimidic acid ethyl ester

1-methyl-1-benzoylhydrazine

→

1-Methyl-3-(o-tolyl)-5-phenyl-1,2,4-triazole

수율 32.0%

용매

diethyl ether

반응 조건

후처리

1. 1
   workup.ADDITIONA mixture of 1.14 g
2. 2
   세척the organic solution is washed with aqueous sodium bicarbonate
3. 3
   건조dried over Na2SO4
4. 4
   기타After evaporation of the solvent
5. 5
   workup.DISTILLATIONthe product is distilled at 170° C./0.1 mm Hg

실험 절차

A mixture of 1.14 g. of o-toluimidic acid ethyl ester, 1.14 g. of 1-methyl-1-benzoylhydrazine and 0.1 g. of o-toluimidic acid ester hydrochloride, as a catalyst, is heated at about 100° C. for three hours under reduced pressure (about 200 mm Hg) and then at about 120° C. for five hours. The raw material is taken up with diethyl ether and the organic solution is washed with aqueous sodium bicarbonate and then dried over Na2SO4. After evaporation of the solvent, the product is distilled at 170° C./0.1 mm Hg. Yield 32%.

출처