반응 #54919

반응 방정식

2-benzoyl-4-chlorophenylisothiocyanate

methyl hydrazine

isothiocyanate

→

N-(2-benzoyl-4-chlorophenyl)-methyl-hydrazinecarbothioamide

수율 91.0%

용매

ethyl ether

ethyl ether

ethyl ether

반응 조건

후처리

1. 1
   온도cooled in an ice bath
2. 2
   workup.STIRRINGthe reaction mixture was stirred at room temperature for about 30 minutes
3. 3
   기타The solid was collected
4. 4
   세척washed with additional ethyl ether

실험 절차

A solution of 5.48 grams (0.02 mole) of 2-benzoyl-4-chlorophenylisothiocyanate in about 50 ml of ethyl ether was added dropwise to a solution containing 1.5 ml (0.028 mole) of methyl hydrazine (98%) in about 50 ml of ethyl ether cooled in an ice bath. Additional ethyl ether was added to facilitate stirring. Following addition of the isothiocyanate, the reaction mixture was stirred at room temperature for about 30 minutes. The solid was collected and washed with additional ethyl ether to yield 5.82 grams (91% yield) of N-(2-benzoyl-4-chlorophenyl)-methyl-hydrazinecarbothioamide as a white solid. The melting point was found to be 168.5°-170° C.

출처