반응 #549131

반응 방정식

p-nitrobenzyl 7-phenylacetamido-3-methylenecepham-4-carboxylate

sulfur dioxide

→

p-Nitrobenzyl 7-phenylacetamido-3-hydroxy-3-cephem-4-carboxylate

용매

methylene chloride

반응 조건

후처리

1. 1
   기타the reaction product was recovered
2. 2
   기타obtained crystalline by extraction with ethyl acetate

실험 절차

Following the ozonization procedures described in Example 9, a solution of 350 mg. of p-nitrobenzyl 7-phenylacetamido-3-methylenecepham-4-carboxylate in 250 ml. of methylene chloride was cooled to -78° C. and was ozonized. The intermediate ozonide was decomposed in situ with sulfur dioxide and the reaction product was recovered and obtained crystalline by extraction with ethyl acetate.

출처