반응 #5491

반응 방정식

Trans 3-mercaptomethyl-2-oxo-1-azacyclodecane-10-carboxylic acid

Acetyl chloride

→

trans 3-(acetylthiomethyl)-2-oxo-1-azacyclodecane-10-carboxylic acid

용매

pyridine

반응 조건

후처리

1. 1
   기타The reaction is quenched
2. 2
   온도by cooling to 0° C.
3. 3
   workup.ADDITIONadding concentrated hydrochloric acid (20 mL)
4. 4
   workup.ADDITIONdiluting with water
5. 5
   추출extracting several times with ethyl acetate
6. 6
   건조The combined organic layers are dried (MgSO4)
7. 7
   기타the solvent is evaporated

실험 절차

Trans 3-mercaptomethyl-2-oxo-1-azacyclodecane-10-carboxylic acid (0.75 g, 3.06 mmol) is dissolved in pyridine (20 mL). Acetyl chloride (0.26 g, 3.37 mmol) is added, and the reaction is stirred at room temperature overnight. The reaction is quenched by cooling to 0° C., adding concentrated hydrochloric acid (20 mL), diluting with water, and extracting several times with ethyl acetate. The combined organic layers are dried (MgSO4), and the solvent is evaporated to give trans 3-(acetylthiomethyl)-2-oxo-1-azacyclodecane-10-carboxylic acid, MS:M+1=288.

출처