반응 #548216
ord-9dcbb9a606b14c8c9b3bed0db9e363fa
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도to maintain a stirrable slurry
- 2온도after which the mixture is cooled
- 3세척The resulting solid is washed with ether
- 4기타recrystallized from acetone/methanol
실험 절차
A mixture of 4.0 g of cis-2-phenylcyclopentylamine hydrochloride, M.P. 205°-206° C and 5.0 ml of O-methylcaprolactim is allowed to stand at room temperature for 6 days with occasional stirring. A few drops of ethanol are added to maintain a stirrable slurry, after which the mixture is cooled. The resulting solid is washed with ether and recrystallized from acetone/methanol to give the desired product, M.P. 181.5°-183.5° C (dec.).