반응 #548206

반응 방정식

α-methyl-p-phenethylbenzylamine hydrochloride

O-methylcaprolactim

→

desired product

수율 76.0%

Hexahydro-2-(α-methyl-p-phenethylbenzylimino)-azepine hydrochloride

수율 76.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타the precipitate is collected
2. 2
   세척washed with small portions of absolute ether
3. 3
   기타recrystallized from a mixture of acetone-methanol

실험 절차

A mixture of 15.0 g of α-methyl-p-phenethylbenzylamine hydrochloride and 25 ml of O-methylcaprolactim is stirred into a slurry and allowed to stand at room temperature for 4 days with occasional stirring. Small portions of absolute ethanol are added to keep the slurry stirrable. The mixture is then cooled to -20° C., the precipitate is collected, washed with small portions of absolute ether and recrystallized from a mixture of acetone-methanol to yield 15.7 g (76% yield) of the desired product, M.P. 230°-231° C.

출처