반응 #54820
ord-e17b2a24b9b4443fb29dd5a58e75c0fb
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출extracted with ether (400 ml total)
- 2세척the extracts washed
- 3건조dried (MgSO4)
- 4기타evaporated
- 5기타The resulting crude solid (2.2 g) is recrystallized from toluene
실험 절차
Sodium hydroxide (0.40 g. of 50% dispersion in mineral oil) is added to 0.61 g. imidazole in 10 ml dimethylformamide and the mixture stirred at room temperature until the evolution of hydrogen is complete. Bromomethyl 2-naphthoyl ketone dimethyl ketal (2.21 g.) in 5 ml. dimethylformamide is then added and the mixture stirred for 24 hours at 110° under nitrogen. The resulting solution is poured into water (400 ml), extracted with ether (400 ml total), and the extracts washed, dried (MgSO4) and evaporated. The resulting crude solid (2.2 g) is recrystallized from toluene to give 1-[2-(2-naphthyl)-2,2-dimethoxyethyl]imidazole as a colorless solid.