반응 #54817

반응 방정식

Methyl 1-naphthyl ketone

chloroform

hydrogen bromide

→

bromomethyl 1-naphthyl ketone

용매

ethyl acetate

반응 조건

후처리

1. 1
   workup.ADDITIONis treated with 26.5 g
2. 2
   기타The resulting reaction mixture
3. 3
   온도is heated
4. 4
   온도under reflux
5. 5
   기타is removed
6. 6
   workup.ADDITIONether is added
7. 7
   기타the copper (I) bromide is removed by filtration
8. 8
   기타Evaporation of the filtrate under reduced pressure

실험 절차

Methyl 1-naphthyl ketone (10.1 g.), in 50 ml of a 1:1 mixture of chloroform and ethyl acetate is treated with 26.5 g. of copper (II) bromide. The resulting reaction mixture is heated under reflux with vigorous stirring until the evolution of hydrogen bromide ceases. When the reaction is complete the solvent is removed, ether is added and the copper (I) bromide is removed by filtration. Evaporation of the filtrate under reduced pressure yields crude bromomethyl 1-naphthyl ketone.

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