반응 #5480

반응 방정식

n-butyllithium hexane

1-azabicyclo[3.2.1]octane-5-methanol

1-methyl-1H-indole-3-carboxylic acid

1,1'-carbonyldiimidazole

→

colorless solid

수율 58.0%

1-Methyl-1H-indole-3-carboxylic acid 1-azabicyclo[3.2.1]oct-5-ylmethyl ester

수율 58.0%

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   기타degassed under a stream of nitrogen over 10 minutes
2. 2
   workup.STIRRINGstirred for 30 minutes
3. 3
   농축concentrated in vacuo
4. 4
   workup.ADDITIONThe suspension of the acid/1,1'-carbonyldiimidazole adduct
5. 5
   workup.STIRRINGthe mixture was stirred 18 hours at room temperature and 4 hours at 55° C.
6. 6
   농축concentrated in vacuo
7. 7
   기타The residue was partitioned between toluene (150 mL)
8. 8
   workup.ADDITIONcontaining some 2-propanol and saturated aqueous sodium carbonate (100 mL)
9. 9
   기타The organic layer was separated
10. 10
    추출the aqueous solution was extracted with toluene (2×100 mL)
11. 11
    workup.ADDITIONcontaining some 2-propanol
12. 12
    건조The combined organic solution was dried (Na2SO4)
13. 13
    농축concentrated in vacuo
14. 14
    여과filtered through alumina (eluted with 20% methanol/tetrahydrofuran)
15. 15
    농축The filtrate was concentrated in vacuo
16. 16
    기타triturated with petroleum ethers (30°-60°)
17. 17
    기타recrystallized from ether/petroleum ethers (2 crops)

실험 절차

A solution of 1-methyl-1H-indole-3-carboxylic acid (1.75 g, 10 mmol) in anhydrous tetrahydrofuran (10 mL) under nitrogen was treated with 1,1'-carbonyldiimidazole (1.79 g, 11 mmol), stirred for one hour, and degassed under a stream of nitrogen over 10 minutes. Meanwhile a cooled (-10° C.) solution of 1-azabicyclo[3.2.1]octane-5-methanol (1.55 g, 11 mmol) in anhydrous tetrahydrofuran (10 mL) under nitrogen was treated (via syringe) with 2.5N n-butyllithium/hexane (10.5 mmol), stirred for 30 minutes, concentrated in vacuo, and taken up in anhydrous tetrahydrofuran (10 mL) under nitrogen. The suspension of the acid/1,1'-carbonyldiimidazole adduct was transferred into this solution, and the mixture was stirred 18 hours at room temperature and 4 hours at 55° C., and concentrated in vacuo. The residue was partitioned between toluene (150 mL) containing some 2-propanol and saturated aqueous sodium carbonate (100 mL). The organic layer was separated and the aqueous solution was extracted with toluene (2×100 mL) containing some 2-propanol. The combined organic solution was dried (Na2SO4), concentrated in vacuo, and filtered through alumina (eluted with 20% methanol/tetrahydrofuran). The filtrate was concentrated in vacuo, triturated with petroleum ethers (30°-60°), and recrystallized from ether/petroleum ethers (2 crops) to afford 1.72 g (58%) of colorless solid; mp 94.5°-96.5° C.

출처