반응 #547366

반응 방정식

3-methoxyphenyl boronic acid

ethyl 2-bromothiazole-4-carboxylate

Na2CO3

→

title compound

Ethyl 2-(3-methoxyphenyl)-thiazole-4-carboxylate

용매

DME

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도to reflux for 20 h
3. 3
   여과filtered
4. 4
   농축concentrated by rotary evaporation
5. 5
   기타purified on silica gel (6:1 hexanes/EtOAc and 4:1 hexanes/EtOAc)

실험 절차

A suspension of 3-methoxyphenyl boronic acid (0.25 g, 1.65 mmol), ethyl 2-bromothiazole-4-carboxylate (0.33 g, 1.4 mmol), PdCl2(dppf)2 (0.11 g) and 2M Na2CO3 (aq) (2 mL) in DME (10 mL) was heated to reflux for 20 h. The mixture was cooled to RT, filtered, concentrated by rotary evaporation and purified on silica gel (6:1 hexanes/EtOAc and 4:1 hexanes/EtOAc) to afford the title compound as a light-brown oil. EI-MS m/z 264 (M+H).

출처