반응 #54696

반응 방정식

1,2,3,4,10,10a-hexahydro-5phenylbenz[g]isoquinoline

sodium carbonate

sodium iodide

isopropylbromide

→

1,2,3,4,10,10a-Hexahydro-2-isopropyl-5-phenylbenz[g]isoquinoline

용매

dimethylformamide

dimethylformamide

반응 조건

후처리

1. 1
   기타are preheated to 50°
2. 2
   온도cooled
3. 3
   workup.ADDITIONpoured onto ice/water
4. 4
   추출The organic substance is extracted with benzene
5. 5
   세척the extracts washed with water
6. 6
   건조dried over sodium sulphate
7. 7
   기타evaporated

실험 절차

A mixture of 22.0 g of 1,2,3,4,10,10a-hexahydro-5phenylbenz[g]isoquinoline, 20.0 g of sodium carbonate and 0.2 g of sodium iodide in 180 ml of dimethylformamide are preheated to 50°. 16.5 g of isopropylbromide in 50 ml of dimethylformamide are added dropwise to the suspension over a 2 hour period, the reaction mixture further stirred for 3.5 hours at the same temperature, cooled and poured onto ice/water. The organic substance is extracted with benzene, the extracts washed with water, dried over sodium sulphate and evaporated and the title compound which remains converted to the fumarate form in isopropyl. M.P. 199°-200°.

출처