반응 #54691

반응 방정식

dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide

3-pyrroline

→

dimethyl 6-(3-pyrrolin-1-yl)-2,4-pyrimidine-dicarbamate-3-oxide

용매

methylene chloride

반응 조건

후처리

1. 1
   workup.ADDITIONA suspension of 12.5 g
2. 2
   기타The white precipitate formed
3. 3
   여과is filtered off
4. 4
   기타recrystallized from a mixture of methylene chloride and methanol, there

실험 절차

A suspension of 12.5 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 100 ml. of methylene chloride is treated with 15 g. of 3-pyrroline and the mixture is stirred at room temperature under an argon atmosphere for 26 hours. The white precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-(3-pyrrolin-1-yl)-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 206° C. (decomposition).

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