반응 #54689

반응 방정식

dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide

piperidine

→

dimethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide

용매

methylene chloride

반응 조건

후처리

1. 1
   workup.ADDITIONA suspension of 7.5 g
2. 2
   기타The white precipitate formed
3. 3
   여과is filtered off
4. 4
   기타recrystallized from a mixture of methylene chloride and methanol, there

실험 절차

A suspension of 7.5 g. of dimethyl 6-chloro-2,4-pyrimidine-dicarbamate-3-oxide in 35 ml. of methylene chloride is treated with 14.5 ml. of piperidine and the mixture is stirred at room temperature under an argon atmosphere for 18 hours. The white precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-piperidino-2,4-pyrimidine-dicarbamate-3-oxide, having a melting point of 202° C. (decomposition).

출처