반응 #54684

반응 방정식

ethanol

2,4-diamino-6-chloropyrimidine

ethanol

sodium hydroxide

3-chloroperbenzoic acid

→

2,4-diamino-6-chloropyrimidine-3-oxide

용매

water

반응 조건

후처리

1. 1
   workup.WAITleft
2. 2
   workup.WAITto stand at 5° C. overnight
3. 3
   여과The solid material is filtered off
4. 4
   기타recrystallized from ethanol, there

실험 절차

75 G. of 2,4-diamino-6-chloropyrimidine are dissolved at 35° C. in 1500 ml. of ethanol. The solution is cooled to -10° C. and a solution of 100 g. of 3-chloroperbenzoic acid in 500 ml. of ethanol is slowly added dropwise within 1 hour. The suspension is subsequently stirred at -10° C. for 7 hours and left to stand at 5° C. overnight. The suspension is neutralized with 24 g. of sodium hydroxide in 100 ml. of water. The solid material is filtered off and recrystallized from ethanol, there being obtained pure 2,4-diamino-6-chloropyrimidine-3-oxide.

출처