반응 #54668

반응 방정식

p-menth-3-oyl chloride

Sodium bicarbonate

4-aminobut-2-yn-1-ol hydrochloride

→

N-(4-hydroxybut-2-ynyl)-p-menthane-3-carboxamide

용매

ether

water

반응 조건

후처리

1. 1
   기타the ether layer separated
2. 2
   건조dried over MgSO4
3. 3
   기타Evaporation of the ether

실험 절차

Sodium bicarbonate (2.5 g.) and 4-aminobut-2-yn-1-ol hydrochloride (2.5 g.) were dissolved in water (60 ml.) and a solution of p-menth-3-oyl chloride in ether (100 ml.) added. The mixture was stirred vigorously for two hours and the ether layer separated and dried over MgSO4. Evaporation of the ether gave N-(4-hydroxybut-2-ynyl)-p-menthane-3-carboxamide as a very viscous liquid: b.p. 180°/0.1 mm.

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