반응 #54663

반응 방정식

p-menth-3-oyl chloride

Sodium bicarbonate

glycine ethyl ester hydrochloride

→

N-p-menth-3-oylglycine ethyl ester

용매

ether

water

반응 조건

후처리

1. 1
   기타At the end of this time the ether layer was separated
2. 2
   건조dried (MgSO4)
3. 3
   기타Removal of the solvent
4. 4
   workup.WAITleft an oily solid (12.3 g.)
5. 5
   workup.DISTILLATIONThis was distilled under reduced pressure

실험 절차

Sodium bicarbonate (8.4 g., 0.1 mole) and glycine ethyl ester hydrochloride (7 g. 0.05 mole) were dissolved in water (100 ml.), and a solution of p-menth-3-oyl chloride (10 g., 0.05 mole) in ether (50 ml.) was added and the mixture stirred vigorously at room temperature for 2 hours. At the end of this time the ether layer was separated and dried (MgSO4). Removal of the solvent left an oily solid (12.3 g.). This was distilled under reduced pressure to yield N-p-menth-3-oylglycine ethyl ester, bp. 150- 2°/0.1 mm. as a colourless liquid which rapidly solidified.

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