반응 #54592
ord-dc120655c6e54af49941a144e86ef0e0
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도This solution is heated
- 2온도is then refluxed for 5 minutes
- 3온도The mixture is refluxed for a further 2 minutes
- 4기타evaporated
- 5세척washed with water
- 6기타dried
- 7기타the solvent removed under vacuo
실험 절차
2-Aminopentanoic acid (0.2 mole) is added to a solution of sodium acetate (0.2 mole) in about 300 ml of glacial acetic acid. This solution is heated to effect solution and is then refluxed for 5 minutes. To the refluxing solution is added (0.2 mole) 2.5-dimethoxytetrahydrofuran as quickly as possible. The mixture is refluxed for a further 2 minutes and the acetic acid is flash evaporated. The residue is taken up in ethyl acetate, washed with water, dried and the solvent removed under vacuo to give 2-(1-pyrryl)pentanoic acid.