반응 #54591
ord-238e2c7868bf4c0ab667f4ccfcc35579
반응 방정식
water
Chloroform
potassium phthalimide
ethyl-2-bromopentanoate
→
ethyl α-phthalimidopentanoate
반응 조건
온도
60°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The phases are separated
- 2추출the aqueous phase is extracted with chloroform
- 3추출extracted with 0.1 N sodium hydroxide and with water
- 4건조After drying over sodium sulfate
- 5기타the chloroform is removed
실험 절차
To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.