반응 #545887

반응 방정식

aluminum trichloride

dichloromethane

2,5-dichloro-2,5-dimethylhexane

phenol

→

title compound

수율 90.8%

5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthol

수율 90.8%

용매

methane dichloride

반응 조건

후처리

1. 1
   온도After cooled
2. 2
   추출extracted with ether (3×80 ml)
3. 3
   세척The organic phase is washed with 10% NaHCO3 solution (2×150 ml)
4. 4
   건조dried over MgSO4
5. 5
   기타evaporated
6. 6
   기타to give a crude product, which
7. 7
   기타is crystallized from ethanol

실험 절차

To a mixture of aluminum trichloride (3.0 g, 22.5 mmol), dichloromethane (50 ml) and 2,5-dichloro-2,5-dimethylhexane (15.0 g, 81.9 mmol) is added dropwise into a solution of phenol (7.7 g, 81.90 mmol) in 50 ml of methane dichloride, then the reaction mixture is heated for 4 hours at 35° C. After cooled, the reaction mixture is poured into ice (200 g) and extracted with ether (3×80 ml). The organic phase is washed with 10% NaHCO3 solution (2×150 ml), dried over MgSO4 and evaporated to give a crude product, which is crystallized from ethanol to give the title compound (15.20 g, 84%).

출처