반응 #54558

반응 방정식

2,2-dimethyl-7-dimethylaminoethyloxy-4-(3-trifluoromethylphenyl)-2H-chromene hydrochloride

hydrogen

→

title compound

수율 74.2%

2,2-Dimethyl-7-dimethylaminoethyloxy-4-(3-trifluoromethylphenyl)chroman hydrochloride

수율 74.2%

용매

ethanol

반응 조건

후처리

1. 1
   기타was hydrogenated under hydrogen (1 atmosphere pressure) at ambient temperature
2. 2
   기타(about 18° C.)
3. 3
   여과The mixture was filtered
4. 4
   기타the solvent removed from the resulting filtrate under reduced pressure

실험 절차

To a solution of 2,2-dimethyl-7-dimethylaminoethyloxy-4-(3-trifluoromethylphenyl)-2H-chromene hydrochloride (4.96 g) in ethanol (75 ml) was added 10% palladium on charcoal. The mixture was hydrogenated under hydrogen (1 atmosphere pressure) at ambient temperature (about 18° C.) until no further hydrogen was taken up. The mixture was filtered and the solvent removed from the resulting filtrate under reduced pressure to yield the title compound (3.7 g), m.p. 188°-190° C.

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