반응 #545398

반응 방정식

(3S)-7,8-Difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzo xazine•p-toluenesulfonate

NaHCO3

→

title compound

수율 124.5%

(3S)-7,8-Difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine

수율 124.5%

용매

AcOEt

반응 조건

후처리

1. 1
   추출the mixture was extracted with AcOEt
2. 2
   건조The organic layer was dried over anhydrous magnesium sulfate
3. 3
   농축concentrated under reduced pressure

실험 절차

(3S)-7,8-Difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzo xazine•p-toluenesulfonate (1 g) was suspended in AcOEt (10 ml) and then an aqueous solution of NaHCO3 (10 ml) was added thereto. After stirring at room temperature for 1 hour, the mixture was extracted with AcOEt. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to thereby give the title compound (645.2 mg, 99.8% ee) as a yellow oily substance. Various spectral data was identical with those obtained in Example 83.

출처