반응 #545278

반응 방정식

2-Bromothiazole-4-carbaldehyde

ethylene glycol

→

product

수율 74.7%

2-Bromo-4-(1,3-dioxolan-2-yl)thiazole

수율 74.7%

용매

toluene

반응 조건

후처리

1. 1
   기타fitted, for 18 hr
2. 2
   농축The product was concentrated
3. 3
   기타purified by column chromatography (15% ethyl acetate/hexane)

실험 절차

2-Bromothiazole-4-carbaldehyde (6.56 g, 34.17 mmol) [A. T. Ung, S. G. Pyne/Tetrahedron: Asymmetry 9 (1998) 1395–1407]and ethylene glycol (5.72 ml, 102.5 mmol) were heated under reflux in toluene (50 ml) with a Dean and Stark trap fitted, for 18 hr. The product was concentrated and purified by column chromatography (15% ethyl acetate/hexane) to give the product as a yellow solid (6.03 g); m/z 236,238.

출처