반응 #54505

반응 방정식

sulfuric acid

2-methylphenylacetyl chloride

ethyl 3-oxobutanoate

magnesium

→

ethyl 2-acetyl-4-(2-methylphenyl)-3-oxobutanoate

용매

ether

carbon tetrachloride

ether

ethanol

반응 조건

후처리

1. 1
   기타This material was prepared
2. 2
   workup.ADDITIONwas added
3. 3
   온도without cooling until the reaction
4. 4
   workup.DISSOLUTIONAfter the resulting precipitate dissolved
5. 5
   온도the solution was cooled in an ice-salt bath
6. 6
   기타The ether layer was separated
7. 7
   세척washed with water
8. 8
   건조dried over sodium sulfate

실험 절차

This material was prepared according to the procedure of M. Viscontini and N. Merckling, Helvetica Chimica Acta, 35, 2280 (1952). To 2.65 parts of magnesium turnings was added 15 parts absolute ethanol at room temperature and 0.5 parts of carbon tetrachloride. As soon as the initial reaction subsides 100 parts of dry ether was added. The mixture was stirred without cooling until the reaction ceased, then 19.6 parts of ethyl 3-oxobutanoate in 20 parts of dry ether was added with ice cooling and good stirring. After the resulting precipitate dissolved, the solution was cooled in an ice-salt bath and 16 parts of 2-methylphenylacetyl chloride was slowly added. The mixture was allowed to stand overnight at room temperature and then combined with ice and sulfuric acid. The ether layer was separated, washed with water, dried over sodium sulfate and stripped to give ethyl 2-acetyl-4-(2-methylphenyl)-3-oxobutanoate as a crude oil.

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