반응 #54487

반응 방정식

hydrochloride

furan-2-yl carboxylic acid chloride

1-phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid 4-methyl piperazide

1-Phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid (4-methyl)-Piperazide

pyridine

→

2-[4-(2-furoyl)-1-piperazinyl]-1-phenyl-indole 3-carboxylic acid 4-methyl-piperazide

용매

chloroform

chloroform

chloroform

반응 조건

후처리

1. 1
   세척the mixture was washed four times with water
2. 2
   여과suction-filtered
3. 3
   세척washed with ether
4. 4
   기타Yield: 19 g (95% of the theoretical yield), m.p. 180°-181° C.
5. 5
   기타decomposed above 300° C.

실험 절차

To a mixture of 16.1 g (0.04 mol) of 1-phenyl-2-(1-piperazinyl)-indole 3-carboxylic acid 4-methyl piperazide (Example 7), 5 ml of pyridine and 40 ml of chloroform, that had been cooled to -20° C., a solution of 6.5 g (0.05 mol) of furan-2-yl carboxylic acid chloride in 80 ml of chloroform was added. The mixture was allowed to stand for 4 hours at room temperature, then 200 ml of chloroform were added and the mixture was washed four times with water. The solvent was eliminated in vacuo, the crystallized residue was digested with ether, suction-filtered and washed with ether. Yield: 19 g (95% of the theoretical yield), m.p. 180°-181° C.; the hydrochloride decomposed above 300° C.

출처