반응 #54479

반응 방정식

sodium acetate

4-Amino-2-bromo-thiazole hydrobromide

trichloroacetyl chloride

pyridine

→

title compound

수율 53.9%

2-Bromo-4-trichloroacetamidothiazole

수율 53.9%

용매

methylene chloride

반응 조건

후처리

1. 1
   온도maintaining
2. 2
   기타reaction temperature at 0° C. with an ice bath
3. 3
   workup.ADDITIONthe addition
4. 4
   workup.STIRRINGthe reaction mixture was stirred at room temperature for 3 hours
5. 5
   workup.STIRRINGstirred for 30 minutes
6. 6
   기타The mixture was separated
7. 7
   세척the organic layer washed with 2N hydrochloric acid, water, sodium carbonate solution and water
8. 8
   건조The organic layer was dried (MgSO4)
9. 9
   기타the solvent removed in vacuo
10. 10
    workup.ADDITIONthe residue treated with charcoal in hexane
11. 11
    기타recrystallised from hexane

실험 절차

4-Amino-2-bromo-thiazole hydrobromide (15.6 g) and trichloroacetyl chloride (14.3 g) were suspended in methylene chloride (100 ml) with stirring and treated dropwise with pyridine (16 ml) over 15 minutes maintaining reaction temperature at 0° C. with an ice bath. After completing the addition, the reaction mixture was stirred at room temperature for 3 hours, then poured onto 20% aqueous sodium acetate (250 ml) and stirred for 30 minutes. The mixture was separated and the organic layer washed with 2N hydrochloric acid, water, sodium carbonate solution and water. The organic layer was dried (MgSO4) and the solvent removed in vacuo and the residue treated with charcoal in hexane and recrystallised from hexane to give the title compound (10.5 g) m.p. 77°-80° C. (Found: C, 19.0; H, 0.7; N, 8.5. C5H2Cl3BrN2OS requires C, 18.5; H, 0.6; N, 8.6%)

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