반응 #544640

반응 방정식

octanoyl chloride

AlCl3

N-ethylcarbazole

benzoyl chloride

AlCl3

→

white solid

octan-1-one

용매

CH2Cl2

반응 조건

후처리

1. 1
   workup.STIRRINGThis reaction mixture is stirred at room temperature for 4.5 h
2. 2
   추출The products are extracted with CH2Cl2
3. 3
   세척The CH2Cl2 layer is washed with water, saturated NaHCO3 aq. solution and with brine
4. 4
   건조by drying over anhydrous MgSO4
5. 5
   기타Purification by column chromatography on silica gel with CH2Cl2-hexane(1:1) as eluent

실험 절차

To 7.83 g (40.1 mmol) of N-ethylcarbazole in 40 mL of CH2Cl2 are added 5.91 g (42.0 mmol) of benzoyl chloride and 5.88 g (44.1 mmol) of AlCl3. After stirring for 4 h at room temperature, 6.89 g (42.3 mmol) of octanoyl chloride and 5.92 g (44.4 mmol) of AlCl3 are added. This reaction mixture is stirred at room temperature for 4.5 h. Then, the reaction mixture is poured into ice-water. The products are extracted with CH2Cl2. The CH2Cl2 layer is washed with water, saturated NaHCO3 aq. solution and with brine, followed by drying over anhydrous MgSO4. Purification by column chromatography on silica gel with CH2Cl2-hexane(1:1) as eluent affords 12.7 g of a white solid (74.2%).

출처