반응 #544175

반응 방정식

2-chloro-6-methoxyquinoline

Br2

→

5-bromo-2-chloro-6-methoxyquinoline

수율 101.7%

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타the mixture was partitioned between NaCl and CH2Cl2
2. 2
   추출The aqueous layer was extracted with CH2Cl2

실험 절차

A solution of 2-chloro-6-methoxyquinoline (4.4 g, 22 mmol) in CH2Cl2 (60 mL) was treated by slow addition of Br2 (3.5 mL, 11 g, 68 mmol). After 14 hours, the mixture was partitioned between NaCl and CH2Cl2. The aqueous layer was extracted with CH2Cl2. The organic layer was worked-up. HPLC (1:10 EtOAc/hexane) gave 6.1 g (99%) of 5-bromo-2-chloro-6-methoxyquinoline as a light yellow solid, (M+) 273(100).

출처