반응 #543926

반응 방정식

tert-Butyl (1-benzyl-4-methyl-4-piperidinyl)-carbamate

tert-Butyl (1-benzyl-4-methyl-4-piperidinyl)carbamate

→

title compound

수율 59.8%

tert-Butyl (4-methyl-4-piperidinyl)carbamate

수율 59.8%

용매

methanol

ethyl acetate

반응 조건

후처리

1. 1
   여과filtered through a pad of Celite
2. 2
   농축concentrated
3. 3
   기타The residual solid was triturated with hexane

실험 절차

tert-Butyl (1-benzyl-4-methyl-4-piperidinyl)-carbamate obtained in Example 10-4 (1.01 g) was dissolved in methanol (20 mL), and 20% Pd(OH)2 on carbon (300 mg) was added. The mixture was stirred under hydrogen atmosphere (4 atm) at 20° C. for 2 hrs. The reaction mixture was diluted with ethyl acetate, filtered through a pad of Celite, and concentrated. The residual solid was triturated with hexane to give the title compound as white crystals (425 mg)

출처