반응 #54381
ord-33ed86bd9a78465cbe69139ce8a64073
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축the solution is carefully concentrated
- 2기타the residue is dried under a high vacuum
- 3기타The residue is purified by thick layer chromatography (toluene/ethyl acetate, 3:1, silica gel)
- 4세척After eluting the silica gel of the zone at Rf = 0.17 with ethyl acetate
- 5농축concentrating the solution
- 6기타on a rotary evaporator
실험 절차
The resulting crude 7β-phenoxyacetamido-3-hydroxy-ceph-3-em-4-carboxylic acid diphenylmethyl ester is dissolved in methanol and a solution of diazomethane in ether is added at 0° C. After 10 minutes, the solution is carefully concentrated and the residue is dried under a high vacuum. The residue is purified by thick layer chromatography (toluene/ethyl acetate, 3:1, silica gel). After eluting the silica gel of the zone at Rf = 0.17 with ethyl acetate, and concentrating the solution on a rotary evaporator, 7β-phenoxyacetamido-3-methoxy-ceph-3-em-4-carboxylic acid diphenylmethyl ester is obtained; melting point 120° C. (from ether).