반응 #5438

반응 방정식

methyl 2-[[2-[4-(5-chloro-2-methoxyphenyl)piperazin- 1-yl]ethyl]amino]-pyrimidine-4-carboxylate

2-[(3-aminopropyl)amino]pyrimidin-4(1H)-one

→

2-[[2-[4-(5-Chloro-2-methoxyphenyl)piperazin-1-yl)ethyl]amino]-N-[3-[(4-oxo-1,4-dihydropyrimidin-2-yl)amino]propyl]pyrimidine-4-carboxamide

용매

n-butanol

반응 조건

후처리

1. 1
   온도The mixture is heated at the reflux temperature of the solvent for 20 hours
2. 2
   기타the solvent is evaporated under reduced pressure

실험 절차

3.0 g (7.4 mmols) of methyl 2-[[2-[4-(5-chloro-2-methoxyphenyl)piperazin- 1-yl]ethyl]amino]-pyrimidine-4-carboxylate and 1.5 g (8.9 mmols) of 2-[(3-aminopropyl)amino]pyrimidin-4(1H)-one in 20 ml of n-butanol are introduced into a 100 ml, round bottomed flask. The mixture is heated at the reflux temperature of the solvent for 20 hours and then the solvent is evaporated under reduced pressure.

출처