반응 #543619

반응 방정식

2-Bromo-3-fluoro anisole

BBr3

→

product

수율 100.1%

2-bromo-3-fluorophenol

수율 100.1%

용매

DCM

반응 조건

후처리

1. 1
   온도The mixture was warmed to r.t.
2. 2
   기타The mixture was partitioned between water and DCM (50 mL)
3. 3
   추출the aqueous layer was back extracted with DCM (200 mL)
4. 4
   건조The combined organics were dried (NaSO4)
5. 5
   여과filtered
6. 6
   농축concentrated

실험 절차

2-Bromo-3-fluoro anisole (10 g, 48.77 mmol) was dissolved in DCM (200 mL) and cooled to about −78° C. To the solution was added BBr3 (11.53 mL, 121.9 mmol) in one portion. The mixture was warmed to r.t. and stirred overnight. The mixture was partitioned between water and DCM (50 mL), and the aqueous layer was back extracted with DCM (200 mL). The combined organics were dried (NaSO4), filtered and concentrated to give about 9.32 g of the product as a dark oil. MS found 188.9 (M−1)

출처