반응 #543538

반응 방정식

isoserine

methanol

HCl

HCl

→

product

수율 92.0%

Methyl 3-amino-2-hydroxypropionate hydrochloride

수율 92.0%

반응 조건

후처리

1. 1
   workup.DISSOLUTIONThe solid material slowly dissolved
2. 2
   기타to yield a pale yellow liquid after a few minutes
3. 3
   기타Excess HCl gas was removed
4. 4
   기타by bubbling nitrogen into the reaction mixture
5. 5
   기타the solvent was removed under reduced pressure

실험 절차

A suspension of isoserine (18) (20.0 g, 0.19 mol) in anhydrous methanol (100 mL) was saturated with HCl gas at 0° C. while being stirred with exclusion of moisture. The solid material slowly dissolved to yield a pale yellow liquid after a few minutes. The HCl saturated solution was stirred overnight (20 h) at room temperature. Excess HCl gas was removed by bubbling nitrogen into the reaction mixture and the solvent was removed under reduced pressure to yield the product as a syrup (27.1 g; yield 92%) Mass Spectrum M+H 120. The product was immediately taken to the next step without further purification.

출처