반응 #543534

반응 방정식

acetate

4-(4-iodophenyl)butyric acid

potassium carbonate

2-hydroxythiophenol

→

4-(4-(2-hydroxyphenyl)thiophenyl)butyric acid

용매

dimethylformamide

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed for 18 hr
2. 2
   온도cooled to 25 C
3. 3
   추출extracted with ethyl acetate
4. 4
   농축The organic phase was concentrated
5. 5
   기타The residue was purified by flash chromatography

실험 절차

A solution of 4-(4-iodophenyl)butyric acid (0.86M) and dimethylformamide was treated with 2 eq of potassium carbonate, 1.5 eq of 2-hydroxythiophenol and a catalytic amount of cuperic acetate (0.01 eq). The reaction mixture was refluxed for 18 hr, cooled to 25 C., acidified with aqueous acid and extracted with ethyl acetate. The organic phase was concentrated. The residue was purified by flash chromatography using ethyl acetate/hexane as eluant to give 4-(4-(2-hydroxyphenyl)thiophenyl)butyric acid.

출처