반응 #54340

반응 방정식

hydrogen

1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-3-hydroxypiperidine

→

title compound

수율 70.0%

3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-3-piperidinol

수율 70.0%

용매

ethanol

반응 조건

후처리

1. 1
   여과The reaction mixture is filtered through diatomaceous earth with ethyl acetate
2. 2
   기타evaporated
3. 3
   기타The residue is recrystallized from ethyl acetate
4. 4
   기타to yield 3.8 g

실험 절차

A mixture of 8.5 (17.03 mmols) of 1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-3-hydroxypiperidine, 2.0 g. of 10% palladium-on-carbon and 60 ml. of ethanol is stirred under one atmosphere of hydrogen for 2 hours. The reaction mixture is filtered through diatomaceous earth with ethyl acetate and evaporated. The residue is recrystallized from ethyl acetate to yield 3.8 g. (70%) of the title compound. A second crop of the title compound 0.396 g. (7%) is obtained from the mother liquor.

출처