반응 #543274

반응 방정식

HCl

3-[1-(4,6-Difluoro-1-methyl-1H-indazol-5-yl)-ethyl]-6-(1-ethoxy-vinyl)-imidazo[1,2-b]pyridazine

NaHCO3

→

title compound

수율 41.0%

1-(3-(1-(4,6-Difluoro-1-methyl-1H-indazol-5-yl)ethyl)imidazo[1,2-b]pyridazin-6-yl)ethanone

수율 41.0%

용매

MeOH

반응 조건

후처리

1. 1
   기타Solvent was evaporated
2. 2
   기타the residue was purified on chromatography (CH2Cl2:MeOH 10:1)

실험 절차

2 mL of 3N HCl solution was added to a solution of 3-[1-(4,6-Difluoro-1-methyl-1H-indazol-5-yl)-ethyl]-6-(1-ethoxy-vinyl)-imidazo[1,2-b]pyridazine in 10 ml MeOH. The reaction solution was stirred at room temperature for 3 hours and then neutralized with sat. NaHCO3 solution. Solvent was evaporated and the residue was purified on chromatography (CH2Cl2:MeOH 10:1) to give the title compound as a yellow solid (30 mg, 41%). LCMS (method C): [MH]+=355.9, tR=3.75 min

출처