반응 #54314

반응 방정식

Dimethyl 2-vinylglutamate hydrochloride

sodium carbonate

→

5-methoxycarbonyl-5-vinyl-2-pyrrolidone

용매

2-methoxyethanol

반응 조건

후처리

1. 1
   추출the resulting mixture extracted with dichloromethane
2. 2
   기타The organic phase is dried
3. 3
   농축concentrated
4. 4
   기타to afford the free base which
5. 5
   온도heated
6. 6
   온도under reflux for 2 hours
7. 7
   기타The solvent is then removed in vacuo

실험 절차

Dimethyl 2-vinylglutamate hydrochloride (570 mg, 2 mM), is treated with saturated aqueous sodium carbonate (20 ml) and the resulting mixture extracted with dichloromethane. The organic phase is dried and concentrated to afford the free base which is dissolved in 2-methoxyethanol (20 ml) and heated under reflux for 2 hours. The solvent is then removed in vacuo to afford 5-methoxycarbonyl-5-vinyl-2-pyrrolidone.

출처