반응 #543096

반응 방정식

Sildenafil citrate

→

Sildenafil

용매

ethanol

Ethanol

반응 조건

후처리

1. 1
   기타to obtain a white precipitate
2. 2
   workup.ADDITIONThe solution is poured out
3. 3
   세척to wash out the unreacted Sildenafil, over night
4. 4
   온도warmed in water bath at 50° C.
5. 5
   온도cooled at room temperature over night

실험 절차

20 g of sodium CMC is dissolved in water to form a 5% viscous aqueous solution (40 ml). Sildenafil citrate (13.3 g) is added to the solution and the mixture is stirred at 50° C. for 1 hr to obtain a white precipitate. The solution is poured out then the ethanol (100 ml) is added for dehydration. Ethanol (100 ml) is added additionally to wash out the unreacted Sildenafil, over night and warmed in water bath at 50° C. and cooled at room temperature over night to obtain the precipitate of Sildenafil-CMC complex (29.6 g).

출처