반응 #54307

반응 방정식

8-amino-5-hydroxy-3,4-dihydrocarbostyril hydrochloride

water

potassium cyanide

water

→

5-hydroxy-8-ureido-3,4-dihydrocarbostyril

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   workup.STIRRINGAfter stirring the mixture for one hour at 50° C.
3. 3
   여과the precipitated crystals were recovered by filtration
4. 4
   세척washed successively with 1 l of water and methanol

실험 절차

10.7 g of 8-amino-5-hydroxy-3,4-dihydrocarbostyril hydrochloride was dissolved in 300 ml of water, and a solution of 4.06 g of potassium cyanide dissolved in 100 ml of water was added thereto while stirring at a temperature of 50° C. After stirring the mixture for one hour at 50° C., the precipitated crystals were recovered by filtration, washed successively with 1 l of water and methanol to obtain 8.75 g of 5-hydroxy-8-ureido-3,4-dihydrocarbostyril as colorless amorphous crystals having a melting point of 209.0°-211.2° C.

출처