반응 #542530

반응 방정식

1,3,4,9-tetrahydro-indeno[2,1-b]pyridin-2-one

acetic acid

→

title compound

cis-1,3,4,4a,9,9a-hexahydro-indeno[2,1-b]pyridin-2-one

용매

methanol

반응 조건

후처리

1. 1
   기타The catalyst is then separated by filtration
2. 2
   농축the filtrate is concentrated
3. 3
   기타The residue is triturated with tert-butyl methyl ether
4. 4
   기타dried

실험 절차

A mixture of 1,3,4,9-tetrahydro-indeno[2,1-b]pyridin-2-one (1.10 g), 10% palladium on carbon (0.15 g), acetic acid (0.75 mL), and methanol (20 mL) is shaken under hydrogen atmosphere (3 bar) at room temperature for 6 h. The catalyst is then separated by filtration and the filtrate is concentrated. The residue is triturated with tert-butyl methyl ether and dried to give the title compound as a colorless solid. Yield: 0.99 g (89% of theory); LC (method 1): tR=2.53 min; Mass spectrum (ESI+): m/z=188 [M+H]+.

출처