반응 #54245

반응 방정식

1,3-diaminopropane

1-benzyl-4-piperidone

→

4-(3-aminopropylamino)-1-benzylpiperidine

용매

ethanol

반응 조건

후처리

1. 1
   기타The starting material is prepared
2. 2
   workup.ADDITIONare added dropwise
3. 3
   여과After theoretical hydrogen-uptake the catalyst is filtered off
4. 4
   기타the filtrate evaporated
5. 5
   workup.DISTILLATIONthe residue distilled
6. 6
   기타the fraction boiling at 145°-160°/0.2 mmHg collected

실험 절차

The starting material is prepared as follows: To the ice cooled stirred solution of 62.5 ml of 1,3-diaminopropane in 100 ml of ethanol, 30 g of 1-benzyl-4-piperidone are added dropwise. The mixture is hydrogenated over 2 g of pre-reduced platinum oxide at 50° and 2.7 atm. for 9 hours. After theoretical hydrogen-uptake the catalyst is filtered off, the filtrate evaporated, the residue distilled and the fraction boiling at 145°-160°/0.2 mmHg collected, to yield the 4-(3-aminopropylamino)-1-benzylpiperidine.

출처