반응 #54237

반응 방정식

Bromine

2-(α-methylbenzyl)acetophenone

→

2-bromo-3-phenylbutyrophenone

용매

diethyl ether

반응 조건

후처리

1. 1
   기타The ether was removed in vacuo
2. 2
   workup.DISSOLUTIONthe residue redissolved in ether (100 ml)
3. 3
   세척washed with saturated sodium bicarbonate solution (2 × 100 ml)
4. 4
   건조water (4 × 100 ml), and dried over anhydrous sodium sulphate
5. 5
   기타Removal of the solvent
6. 6
   기타gave a solid which
7. 7
   기타on recrystallisation from petroleum ether (40°-60°)

실험 절차

Bromine (0.02 mol) was added dropwise to a stirred solution of 2-(α-methylbenzyl)acetophenone (0.02 mol) in dry diethyl ether (20 ml) at 5° over one hour. The ether was removed in vacuo and the residue redissolved in ether (100 ml), washed with saturated sodium bicarbonate solution (2 × 100 ml) and then water (4 × 100 ml), and dried over anhydrous sodium sulphate. Removal of the solvent gave a solid which on recrystallisation from petroleum ether (40°-60°) gave 2-bromo-3-phenylbutyrophenone, m.p. 69°-71°.

출처