반응 #5418

반응 방정식

2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline

hydrochloric acid

→

2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline

수율 46.5%

용매

ethanol water

반응 조건

후처리

1. 1
   온도was refluxed for 3 hours
2. 2
   기타Ethanol was removed by distillation under reduced pressure
3. 3
   추출extracted with ethyl acetate
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   기타The solvent was removed by distillation under reduced pressure

실험 절차

A mixture of 2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38 %, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound (xi)).

출처