반응 #54136

반응 방정식

1-Benzyl-3-bromo-benzene

NaOt-Bu

P(o-tolyl)3

3-(S)-Isopropyl-piperazine-1-carboxylic acid tert-butyl ester

→

4-(3′-Benzylphenyl)-3-(S)-iso-propyl-piperazine-1-carboxylic acid tert-butyl ester

수율 22.7%

용매

hexanes EtOAc

CH2Cl2 MeOH

toluene

반응 조건

후처리

1. 1
   여과After filtrating the reaction mixture through celite the solvent
2. 2
   기타was evaporated

실험 절차

17.9 mg (19.55 μmol, 0.044 eq.) Pd2(dba)3 and 5.9 mg (19.38 μmol, 0.044 eq.) P(o-tolyl)3 were dissolved in 6 ml dry toluene. Then 58.9 mg (610 μmol, 1.39 eq.) NaOt-Bu was added, followed by a solution of 101 mg (442 μmol) 3-(S)-Isopropyl-piperazine-1-carboxylic acid tert-butyl ester (85) and 110 mg (445 μmol, 1.01 eq.) 1-Benzyl-3-bromo-benzene (87). The resulting mixture was heated at 100° C. for 19 h. After filtrating the reaction mixture through celite the solvent was evaporated. Column chromatography (hexanes/EtOAc (3+1)) yielded 39.6 mg (100 μmol, 22.71%) 4-(3′-Benzylphenyl)-3-(S)-iso-propyl-piperazine-1-carboxylic acid tert-butyl ester (88).

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