반응 #540878

반응 방정식

(R)—((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)acetate

2-bromo-1-o-tolylethanone

→

(R)-1-(2-oxo-2-o-tolylethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide

수율 86.4%

용매

EtOAc

반응 조건

후처리

1. 1
   여과The precipitate was collected by suction filtration

실험 절차

To a solution of (R)—((R)-quinuclidin-3-yl) 2-phenyl-2-(phenylamino)acetate (diastereomer 1 of I2) (55 mg, 0.16 mmol) in EtOAc (5 ml), was added 2-bromo-1-o-tolylethanone (41.8 mg, 0.20 mmol), and the reaction was stirred at room temperature for 15 hours. The precipitate was collected by suction filtration to obtain (R)-1-(2-oxo-2-o-tolylethyl)-3-((R)-2-phenyl-2-(phenylamino)acetoxy)-1-azoniabicyclo[2.2.2]octane bromide (76.0 mg, 85% yield).

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