반응 #53907

ord-5b3d621d7d1e4c6a854552f348939299

반응 방정식

CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1.O=C(O)C(F)(F)F
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride
CNC
dimethlamine
→
CN(C)CCCC[C@H]1CC[C@H](N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1
trans-N-[4-(4-Dimethylamino-butyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide

반응물

CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1.O=C(O)C(F)(F)F
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride
CNC
dimethlamine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester-trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with dimethlamine to give trans-N-[4-(4-Dimethylamino-butyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 421 (MH+).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06858651B2uspto-grants-2005_02