반응 #53906

ord-e74626a95eab41999b9c302c2e05234f

반응 방정식

C1CCNCC1
piperidine
CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester
O=C(O)C(F)(F)F
trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride
CN([C@H]1CC[C@H](CCCCN2CCCCC2)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
trans-N-Methyl-N-[4-(4-piperidin-1-yl-butyl)-cyclohexyl]-4-trifluoromethyl-benzenesulfonamide

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with piperidine to give trans-N-Methyl-N-[4-(4-piperidin-1-yl-butyl)-cyclohexyl]-4-trifluoromethyl-benzenesulfonamide, MS: 461 (MH+).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06858651B2uspto-grants-2005_02