반응 #53904

ord-9b7c69e8bf6440608ef6f7ab93b482bf

반응 방정식

C=CCNC
N-allyl-N-methylamine
CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester
O=C(O)C(F)(F)F
trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride
→
C=CCN(C)CCCC[C@H]1CC[C@H](N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1
trans-N-{4-[4-(Allyl-methyl-amino)-butyl]-cyclohexyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide

반응물

C=CCNC
N-allyl-N-methylamine
CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester
O=C(O)C(F)(F)F
trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with N-allyl-N-methylamine to give trans-N-{4-[4-(Allyl-methyl-amino)-butyl]-cyclohexyl}-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 447 (MH+).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06858651B2uspto-grants-2005_02