반응 #53891

ord-363ba151df3a46a1b8bfb562610906bc

반응 방정식

CCNCC
diethylamine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl sulfonylchloride
→
CCN(CC)CCCCC[C@H]1CC[C@H](N(C)S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1
trans N-[4-(5-Diethylamino-pentyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide

반응물

CCNCC
diethylamine
CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester
O=C(O)C(F)(F)F
trifluoroacetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl sulfonylchloride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester.trifluoroacetic acid salt and 4-trifluoromethyl-phenyl sulfonylchloride were reacted, followed by treatment with diethylamine to give trans N-[4-(5-Diethylamino-pentyl)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide. MS: 463 (MH+).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06858651B2uspto-grants-2005_02